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gtbop-archive-site/site/structural/2017-10-18-scharf-insecticide-moa/activities/matching/index.html
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Rich Braman 1b4b58139c Re-publish Scharf Insecticide MOA session with updated deliverables 
Co-Authored-By: Claude Opus 4.6 (1M context) <noreply@anthropic.com>
2026-03-17 22:16:54 -04:00

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<h1 id="gtbop-moodle-matching-exercises">GTBOP Moodle Matching Exercises<a class="headerlink" href="#gtbop-moodle-matching-exercises" title="Permanent link">&para;</a></h1>
<h2 id="principles-of-insecticide-mode-of-action-dr-michael-scharf">Principles of Insecticide Mode of Action — Dr. Michael Scharf<a class="headerlink" href="#principles-of-insecticide-mode-of-action-dr-michael-scharf" title="Permanent link">&para;</a></h2>
<p><strong>Webinar Date:</strong> October 18, 2017
<strong>Series:</strong> Structural Pest Control
<strong>Activity Type:</strong> Matching Exercises
<strong>Exercises:</strong> 3
<strong>Total Pairs:</strong> 26 (8 + 10 + 8)</p>
<hr />
<h3 id="chain-of-custody">CHAIN OF CUSTODY<a class="headerlink" href="#chain-of-custody" title="Permanent link">&para;</a></h3>
<ul>
<li><strong>Source documents:</strong> Corrected SRT (GTBOP_Transcript_2017-10-18_InsecticideMOA.srt) + Archive Package (GTBOP_Archive_Summary_2017-10-18_InsecticideMOA.md)</li>
<li><strong>All terms, definitions, and relationships derived exclusively from presentation content</strong></li>
</ul>
<hr />
<h3 id="matching-exercise-1-insecticide-classes-and-their-target-sites">Matching Exercise 1: Insecticide Classes and Their Target Sites<a class="headerlink" href="#matching-exercise-1-insecticide-classes-and-their-target-sites" title="Permanent link">&para;</a></h3>
<p><strong>Timestamp Reference:</strong> 28:40 – 39:05 (primary coverage area)
<strong>Type:</strong> Product-Target Site Matching</p>
<p><strong>Instructions:</strong> Match each insecticide class in Column A with the target site it affects in Column B. Note: Column B contains two extra items.</p>
<table>
<thead>
<tr>
<th>#</th>
<th>Column A</th>
<th></th>
<th>Column B</th>
</tr>
</thead>
<tbody>
<tr>
<td>1</td>
<td>Pyrethroids</td>
<td></td>
<td>a) Chloride channels</td>
</tr>
<tr>
<td>2</td>
<td>Fipronil (phenylpyrazole)</td>
<td></td>
<td>b) Acetylcholine receptor</td>
</tr>
<tr>
<td>3</td>
<td>Nicotinoids</td>
<td></td>
<td>c) Muscular calcium channels</td>
</tr>
<tr>
<td>4</td>
<td>Organophosphates and carbamates</td>
<td></td>
<td>d) Axonal sodium channels</td>
</tr>
<tr>
<td>5</td>
<td>Diamides (chlorantraniliprole)</td>
<td></td>
<td>e) Acetylcholinesterase enzyme</td>
</tr>
<tr>
<td>6</td>
<td>Indoxacarb (oxadiazine)</td>
<td></td>
<td>f) Mitochondria (energy production)</td>
</tr>
<tr>
<td>7</td>
<td>Abamectin (avermectin)</td>
<td></td>
<td>g) Chitin synthesis enzymes</td>
</tr>
<tr>
<td>8</td>
<td>Chitin synthesis inhibitors</td>
<td></td>
<td>h) Glutamate-gated chloride channels</td>
</tr>
<tr>
<td></td>
<td></td>
<td></td>
<td>i) Juvenile hormone receptors</td>
</tr>
<tr>
<td></td>
<td></td>
<td></td>
<td>j) Axonal sodium channels (blockage)</td>
</tr>
</tbody>
</table>
<p><strong>Answer Key:</strong>
1 → d, 2 → a, 3 → b, 4 → e, 5 → c, 6 → j, 7 → h, 8 → g</p>
<p><strong>Notes:</strong>
- Items 1 and 6 both target sodium channels but through opposite mechanisms (stimulation vs. blockage), which is why they map to separate entries (d and j). This distinction is a key teaching point from the presentation.
- Distractors: (f) mitochondria and (i) juvenile hormone receptors are legitimate target sites discussed elsewhere in the presentation but do not match the classes listed in Column A.</p>
<p><strong>Source in transcript:</strong> Blocks 301–343 (target site roadmap), 346–362 (sodium channels), 363–387 (chloride channels), 388–407 (acetylcholine), 429–444 (diamides), 466–482 (IGRs)</p>
<hr />
<h3 id="matching-exercise-2-insecticide-mode-of-action-effects">Matching Exercise 2: Insecticide Mode of Action Effects<a class="headerlink" href="#matching-exercise-2-insecticide-mode-of-action-effects" title="Permanent link">&para;</a></h3>
<p><strong>Timestamp Reference:</strong> 17:51 – 47:00 (spans full classification section)
<strong>Type:</strong> Product-Effect Matching</p>
<p><strong>Instructions:</strong> Match each insecticide or insecticide class in Column A with the physiological effect it produces in insects, as described by Dr. Scharf, in Column B. Note: Column B contains two extra items.</p>
<table>
<thead>
<tr>
<th>#</th>
<th>Column A</th>
<th></th>
<th>Column B</th>
</tr>
</thead>
<tbody>
<tr>
<td>1</td>
<td>Pyrethroids / pyrethrins</td>
<td></td>
<td>a) Blocks chloride channels, causing nervous system excitation</td>
</tr>
<tr>
<td>2</td>
<td>Fipronil</td>
<td></td>
<td>b) Stimulates muscular calcium channels, causing contraction followed by energy depletion and paralysis</td>
</tr>
<tr>
<td>3</td>
<td>Indoxacarb</td>
<td></td>
<td>c) Stimulates sodium channels, causing rapid knockdown and excitation</td>
</tr>
<tr>
<td>4</td>
<td>Organophosphates</td>
<td></td>
<td>d) Inhibits chitin synthesis enzyme, causing death during molting</td>
</tr>
<tr>
<td>5</td>
<td>Diamides</td>
<td></td>
<td>e) Blocks sodium channels, causing paralysis ("on switch stuck in off position")</td>
</tr>
<tr>
<td>6</td>
<td>Juvenile hormone analogs (pyriproxyfen)</td>
<td></td>
<td>f) Inhibits acetylcholinesterase, causing excitation from neurotransmitter buildup</td>
</tr>
<tr>
<td>7</td>
<td>Chitin synthesis inhibitors</td>
<td></td>
<td>g) Mimics juvenile hormone, causing cuticle deformation and extra juvenile stages</td>
</tr>
<tr>
<td>8</td>
<td>Abamectin</td>
<td></td>
<td>h) Stimulates chloride channels, causing inhibition and paralysis</td>
</tr>
<tr>
<td>9</td>
<td>Silica gel / diatomaceous earth</td>
<td></td>
<td>i) Abrades waxy cuticle layer, causing water loss and dehydration</td>
</tr>
<tr>
<td>10</td>
<td>Nicotinoid-pyrethroid combinations</td>
<td></td>
<td>j) Stimulates acetylcholine receptors and sodium channels simultaneously (potentiation)</td>
</tr>
<tr>
<td></td>
<td></td>
<td></td>
<td>k) Disrupts mitochondrial respiration, depleting cellular energy</td>
</tr>
<tr>
<td></td>
<td></td>
<td></td>
<td>l) Blocks acetylcholine receptors, preventing nerve signal transmission</td>
</tr>
</tbody>
</table>
<p><strong>Answer Key:</strong>
1 → c, 2 → a, 3 → e, 4 → f, 5 → b, 6 → g, 7 → d, 8 → h, 9 → i, 10 → j</p>
<p><strong>Notes:</strong>
- This exercise tests understanding of both the target site AND the specific mode of action (stimulation vs. blockage vs. inhibition) — the core teaching framework of the presentation.
- Distractors: (k) mitochondrial disruption is discussed for products like hydramethylnon but is not paired with any Column A item; (l) is a plausible-sounding but incorrect mechanism not described in the presentation.</p>
<p><strong>Source in transcript:</strong> Blocks 184–205 (four modes of action), 346–362 (sodium channels), 363–387 (chloride channels), 388–407 (acetylcholine), 408–420 (combinations), 429–444 (diamides), 466–482 (IGRs), 499–511 (dusts)</p>
<hr />
<h3 id="matching-exercise-3-practical-factors-affecting-insecticide-performance">Matching Exercise 3: Practical Factors Affecting Insecticide Performance<a class="headerlink" href="#matching-exercise-3-practical-factors-affecting-insecticide-performance" title="Permanent link">&para;</a></h3>
<p><strong>Timestamp Reference:</strong> 48:15 – 56:30 (practical factors section)
<strong>Type:</strong> Timing-Practice Matching</p>
<p><strong>Instructions:</strong> Match each practical factor or scenario in Column A with the correct explanation or outcome described by Dr. Scharf in Column B. Note: Column B contains two extra items.</p>
<table>
<thead>
<tr>
<th>#</th>
<th>Column A</th>
<th></th>
<th>Column B</th>
</tr>
</thead>
<tbody>
<tr>
<td>1</td>
<td>Excess food in a cockroach account</td>
<td></td>
<td>a) Can pass insecticide through two digestive tracts and still affect a third individual</td>
</tr>
<tr>
<td>2</td>
<td>Dirt and grease on treated surfaces</td>
<td></td>
<td>b) Physically bind and tie up insecticides, reducing their effectiveness</td>
</tr>
<tr>
<td>3</td>
<td>Cockroach secondary/tertiary kill</td>
<td></td>
<td>c) Enables slow-acting insecticides to spread through food sharing and grooming</td>
</tr>
<tr>
<td>4</td>
<td>Trophallaxis and allogrooming in social insects</td>
<td></td>
<td>d) Competes directly with bait placements, reducing consumption by target pests</td>
</tr>
<tr>
<td>5</td>
<td>Flea larvae exposed through adult flea feces</td>
<td></td>
<td>e) Causes the insecticide's active ingredient to degrade faster in the environment</td>
</tr>
<tr>
<td>6</td>
<td>UV light exposure on raw insecticides</td>
<td></td>
<td>f) Larvae consume insecticide-laden feces of treated adults as a nutritional source</td>
</tr>
<tr>
<td>7</td>
<td>Formulations (inerts, stabilizers, attractants)</td>
<td></td>
<td>g) Enhance stability, extend longevity, improve safety, and keep active ingredients dissolved in water</td>
</tr>
<tr>
<td>8</td>
<td>Product rotation every 3 months or monthly</td>
<td></td>
<td>h) Helps manage resistance by alternating between different modes of action</td>
</tr>
<tr>
<td></td>
<td></td>
<td></td>
<td>i) Increases the LD50 of the product, making it less toxic to target pests</td>
</tr>
<tr>
<td></td>
<td></td>
<td></td>
<td>j) Converts neurotoxic insecticides into non-repellent formulations</td>
</tr>
</tbody>
</table>
<p><strong>Answer Key:</strong>
1 → d, 2 → b, 3 → a, 4 → c, 5 → f, 6 → e, 7 → g, 8 → h</p>
<p><strong>Notes:</strong>
- This exercise bridges the gap between toxicology and practice — the section of the presentation Scharf described as "where toxicology interfaces with practice."
- Distractors: (i) is plausible-sounding but reverses the relationship (formulations don't increase LD50 for targets); (j) is a fabricated mechanism not described in the presentation.</p>
<p><strong>Source in transcript:</strong> Blocks 515–547 (stability and formulations), 548–567 (pest behavior), 568–585 (sanitation), 586–611 (resistance management)</p>
<hr />
<h2 id="moodle-activity-verification">Moodle Activity Verification<a class="headerlink" href="#moodle-activity-verification" title="Permanent link">&para;</a></h2>
<ul>
<li>[x] All terms, definitions, and relationships derived from presentation content</li>
<li>[x] Timestamp references verified against corrected SRT</li>
<li>[x] No external knowledge required to answer correctly</li>
<li>[x] Matching items unambiguous based on presentation content</li>
<li>[x] 1–2 plausible distractors included per exercise to prevent elimination guessing</li>
<li>[x] Answer keys unambiguously correct per speaker's content</li>
<li>[x] Exercises cover early (target sites), middle (modes of action and effects), and late (practical factors) presentation content</li>
</ul>
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